Recent Publications

Otsugu M, Mine A, Utida I, Miyake Y, Tachihara R, Fujiwara K, Ichimura A, Sato K, Tomura H
Low pH modulates lipopolysaccharide-induced tumor necrosis factor-alpha expression and macropinocytotic activity in RAW264.7 cells.
J Recept Signal Transduct Res  44: 63-71 (2024) [PubMed]

Deai M, Oya R, Saso N, Tanaka A, Uchida I, Miyake Y, Tachihara R, Otsugu M, Mine A, Sato K, Tomura H
Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells.
Biochem Biophys Res Commun  626: 15-20 (2022) [PubMed]

Kadowaki M, Sato K, Kamio H, Kumagai M, Sato R, Nyui T, Umeda Y, Waseda Y, Anzai M, Aoki-Saito H, Koga Y, Hisada T, Tomura H, Okajima F, Ishizuka T
Metal-Stimulated Interleukin-6 Production Through a Proton-Sensing Receptor, Ovarian Cancer G Protein-Coupled Receptor 1, in Human Bronchial Smooth Muscle Cells: A Response Inhibited by Dexamethasone.
J Inflamm Res  14: 7021-7034 (2021) [PubMed]

Sato K, Tobo A, Mogi C, Tobo M, Yamane N, Tosaka M, Tomura H, Im D-S, Okajima F
The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model.
Sci Rep  10: 17193 (2020) [PubMed]

Sato K, Mogi C, Mighell AJ, Okajima F
A missense mutation of Leu74Pro of OGR1 found in familial amelogenesis imperfecta actually causes the loss of the pH-sensing mechanism.
Biochem Biophys Res Commun  526: 920-926 (2020) [PubMed]

Musha S, Yoshida S, Murakami S, Kojima R, Deai M, Saso N, Mogi C, Sato K, Okajima F, Tomura H
Involvement of GPR4 in increased growth hormone and prolactin expressions by 1 extracellular acidification in MtT/S cells.
J Reprod Dev  66: 175-180 (2020) [PubMed]

Murakami S, Mochimaru Y, Musha S, Kojima R, Deai M, Mogi C, Sato K, Okajima F, Tomura H
Species-dependent enhancement of ovarian cancer G protein-coupled receptor 1 activation by ogerin.
Zoolog Sci  37: 103-108 (2020) [PubMed]

Kojima R, Horiguchi K, Mochimaru Y, Musha S, Murakami S, Deai M, Mogi C, Sato K, Okajima F, Tomura H
Characterization of molecular mechanisms of extracellular acidification-induced intracellular Ca2+ increase in LβT2 cells.
Biochem Biophys Res Commun  517: 636-641 (2019) [PubMed]

Musha S, Nagayama S, Murakami S, Kojima R, Deai M, Sato K, Okajima F, Ueharu H, Tomura H
Protons Differentially Activate TDAG8 Homologs from Various Species.
Zoolog Sci  36: 105-111 (2019) [PubMed]

Kadowaki M, Yamada H, Sato K, Shigemi H, Umeda Y, Morikawa M, Waseda Y, Anzai M, Kamide Y, Aoki-Saito H, Hisada T, Okajima F, Ishizuka T
Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone.
J Inflamm (Lond)  16: 4 (2019) [PubMed]

Mochimaru Y, Negishi J, Murakami S, Musha S, Sato K, Okajima F, Tomura H
Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species.
Zoolog Sci  35: 109-114 (2018) [PubMed]

Nagasaka A, Mogi C, Ono H, Nishi T, Horii Y, Ohba Y, Sato K, Nakaya M, Okajima F, Kurose H
The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction.
Sci Rep  7: 7812 (2017) [PubMed]

Negishi J, Omori Y, Shindo M, Takanashi H, Musha S, Nagayama S, Hirayama J, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Mochimaru Y, Tomura H
Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4.
J Recept Signal Transduct Res  37: 401-408 (2017) [PubMed]

Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Nat Commun 8: 28 (2017) [PubMed]

Uchiyama T, Okajima F, Mogi C, Tobo A, Tomono S, Sato K
Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue.
PLoS One 12: e0178769 (2017) [PubMed]

Lee KP, Park SJ, Kang S, Koh JM, Sato K, Chung HY, Okajima F, Im DS
Omega-3 polyunsaturated fatty acids accelerate airway repair by activating FFA4 in club cells.
Am J Physiol Lung Cell Mol Physiol 312: L835-L844 (2017) [PubMed]

Parry DA, Smith CEL, El-Sayed W, Poulter JA, Shore RC, Logan CV, Mogi C, Sato K, Okajima F, Harada A, Zhang H, Koruyucu M, Seymen F, Hu JC-C, Simmer JP, Ahmed M, Jafri H, Johnson CF, Inglehearn CF, Mighell AJ
Mutations in the pH Sensing G-protein Coupled Receptor GPR68 cause Amelogenesis Imperfecta.
Am J Hum Genet 99: 984-990 (2016) [PubMed]

Sato K, Okajima F, Miyashita K, Imamura S, Kobayashi J, Stanhope KL, Havel PJ, Machida T, Sumino H, Murakami M, Schaefer E, Nakajima K
The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins.
Clin Chim Acta 461: 114-125 (2016) [PubMed]

Ichijo Y, Mochimaru Y, Azuma M, Satou K, Negishi J, Nakakura T, Oshima N, Mogi C, Sato K, Matsuda K, Okajima F, Tomura H
Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment.
Biochem Biophys Res Commun 469: 81-86 (2016) [PubMed]

Tsurumaki H, Mogi C, Aoki-Saito H, Tobo M, Kamide Y, Yatomi M, Sato K, Dobashi K, Ishizuka T, Hisada T, Yamada M, Okajima F
Protective role of proton-sensing TDAG8 in lipopolysaccharide-induced acute lung injury.
Int J Mol Sci 16: 28931-28942 (2015) [PubMed]

Uchiyama T, Tomono S, Sato K, Nakamura T, Kurabayashi M, Okajima F
Angiotensin II Reduces Lipoprotein Lipase Expression in Visceral Adipose Tissue via Phospholipase C ｲ 4 Depending on Feeding but Increases Lipoprotein Lipase Expression in Subcutaneous Adipose Tissue via c-Src.
PLoS One 10: e0139638 (2015) [PubMed]

Kamide Y, Ishizuka T, Tobo M, Tsurumaki H, Aoki H, Mogi C, Nakakura T, Yatomi M, Ono A, Koga Y, Sato K, Hisada T, Dobashi K, Yamada M, Okajima F
Acidic environment augments Fcｵ RI-mediated production of IL-6 and IL-13 in mast cells.
Biochem Biophys Res Commun 464: 949-955 (2015) [PubMed]

Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi C, Im DS, Murata N, Kuwabara A, Ito S, Fukuda H, Arisawa M, Shuto S, Nakaya M, Kurose H, Sato K, Okajima F
Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses.
PLoS One 10: e0129334 (2015) [PubMed]

An C, Sato K, Wu T, Bao M, Bao L, Tobo M, Damirin A
Extracellular acidification synergizes with PDGF to stimulate migration of mouse embryo fibroblasts through activation of p38MAPK with a PTX-sensitive manner.
Biochem Biophys Res Commun 460: 191-197 (2015) [PubMed]

Mochimaru Y, Azuma M, Oshima N, Ichijo Y, Satou K, Matsuda K, Asaoka Y, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Tomura H
Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment.
Biochem Biophys Res Commun 457: 493-499 (2015) [PubMed]

Park SJ, Lee KP, Kang S, Lee J, Sato K, Chung HY, Okajima F, Im DS
Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4.
Cell Signal 26: 2249-2258 (2014) [PubMed]

Kotake M, Sato K, Mogi C, Tobo M, Aoki H, Ishizuka T, Sunaga N, Imai H, Kaira K, Hisada T, Yamada M, Okajima F
Acidic pH increases cGMP accumulation through the OGR1/phospholipase C/Ca2+/neuronal NOS pathway in N1E-115 neuronal cells.
Cell Signal 26: 2326-2332 (2014) [PubMed]

Sato K, Tobo M, Mogi C, Murata N, Kotake M, Kuwabara A, Im DS, and Okajima F
Lipoprotein-associated lysolipid molecules are differentially involved in high-density lipoprotein- and its oxidized form-induced neurite remodeling in PC12 cells.
Neurochem Int 68: 38-47 (2014) [PubMed]

Jin Y, Sato K, Ayaka Tobo, Mogi C, Tobo M, Murata N, Ishii S, Im DS, Okajima F
Inhibition of interleukin-1? production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia.
J Neurochem 129: 683-695 (2014) [PubMed]

Aoki H, Mogi C, Hisada T, Nakakura T, Kamide Y, Ichimonji I, Tomura H, Tobo M, Sato K, Tsurumaki H, Dobashi K, Mori T, Harada A, Yamada M, Mori M, Ishizuka T, Okajima F
Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model.
PLoS One 8: e79985 (2013) [PubMed]

Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Endocrinology 153: 4171-4180 (2012) [PubMed]

Komachi M, Sato K, Tobo M, Mogi C, Yamada T, Ohta H, Tomura H, Kimura T, Im DS, Yanagida K, Ishii S, Takeyoshi I, Okajima F
An orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Cancer Sci 103: 1099-1104 (2012) [PubMed]

He XD, Tobo M, Mogi C, Nakakura T, Komachi M, Murata N, Takano M, Tomura H, Sato K, Okajima F
Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages
Biochem Biophys Res Commun 415: 627-631 (2011) [PubMed]

Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, Okajima F
Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells.
Biochem Biophys Res Commun 413: 499-503 (2011) [PubMed]

Sato K, Horiuchi Y, Jin Y, Malchinkhuu E, Komachi M, Kondo T, Okajima F
Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1ｲ -induced attenuation of Rho signaling pathways in rat astrocytes.
J Neurochem 117: 164-174 (2011) [PubMed]

Sato K, Okajima F
Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein.
World J Biol Chem 1: 327-337 (2010) [PubMed]

Ichimonji I, Tomura H, Mogi C, Sato K, Aoki H, Hisada H, Dobashi K, Ishizuka T, Mori M, Okajima F
Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-Sensing OGR1 receptors in human airway smooth muscle cells.
Am J Physiol-Lung Cell Mol Physiol 299: L567-577 (2010) [PubMed]

Liu JP, Komachi M, Tomura H, Mogi C, Damirin A, Tobo M, Takano M, Nochi H, Tamoto K, Sato K, Okajima F
Ovarian cancer G-protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells.
Am J Physiol-Heart Circ Physiol 299: 731-742 (2010) [PubMed]

Liu JP, Nakakura T, Tomura H, Tobo M, Mogi C, Wang JQ, He XD, Takano M, Damirin A, Komachi M, Sato K, Okajima F
Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.
Pharmacol Res 61: 499-505 (2010) [PubMed]

Kimura T, Sato K, Tomura H, Okajima F
Cross-talk Between Exogenous Statins and Endogenous High-density Lipoprotein in Anti-inflammatory and Anti-atherogenic Actions.
Endocrine, Metabolic and Immune Disorder-Drug Targets (EMID-DT) 10: 8-15 (2010) [PubMed]

Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F
Mechanism and role of high-density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.
J Biol Chem 285: 4387-4397 (2010) [PubMed]

Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells.
Mol Biol Cell 20: 5156-5165 (2009) [PubMed]

Murata N, Mogi C, Tobo M, Nakakura T, Sato K, Tomura H, Okajima F
Inhibition of superoxide anion production by extracellular acidification in neutrophils.
Cell Immunol 59: 21-26 (2009) [PubMed]

Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Pro-Inflammatory Cytokine Production In Peritoneal Macrophages.
J Immunol 182: 3243-3251 (2009) [PubMed]

Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
Carcinogenesis 30: 457-465 (2009) [PubMed]

Komachi M, Damirin A, Malchinkhuu E, Mogi C, Tobo M, Ohta H, Sato K, Tomura H, Okajima F
Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells.
Vasc Pharmacol 50: 178-184 (2009) [PubMed]

Okajima F, Sato K, Kimura T
Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I.
Endocrine J 56:317-334 (2009) [PubMed]

Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F
Induction of Scavenger Receptor Class B Type I is Critical for Simvastatin Enhancement of High-Density Lipoprotein-induced Anti-Inflammatory Actions in Endothelial Cells.
J Immunol 181:7332-7340 (2008) [PubMed]

Nochi H, Tomura H, Tobo M, Tanaka N, Sato K, Shinozaki T, Kobayashi T, Takagishi K, Ohta H, Okajima F, Tamoto K
Stimulatory Role of Lysophosphatidic Acid in COX-2 Induction by Synovial Fluid of Patients with Rheumatoid Arthritis in Fibroblast-like Synovial Cells.
J Immunol 181:5111-5119 (2008) [PubMed]

Tomura H, Wang JQ, Liu JP, Komachi M, Damirin A, Mogi C, Tobo M, Noch i H, Tamoto K, Im DS, Sato K, Okajima F
Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line.
J Bone Miner Res 23:1129-1139 (2008) [PubMed]

Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H, Okajima F
S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Biochem Biophys Res Commun. 366: 963-968 (2008) [PubMed]

Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F
Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.
J Neurochem. 103: 2610-2619 (2007) [PubMed]

Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F
HDL-like lipoproteins in cerebrospinal fluid affect neural cell activitythrough lipoprotein-associated sphingosine 1-phosphate.
Biochem Biophys Res Commun. 359:649-654 (2007) [PubMed]

Tobo M, Tomura H, Mogi C, Wang JQ, Liu JP, Komachi M, Damirin A, Kimura T, Murata N, Kurose H, Sato K, Okajima F
Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
Cell Signal. 19: 1745-1753 (2007) [PubMed]

Damirin A, Tomura H, Komachi M, Liu JP, Mogi C, Tobo M, Wang JQ, Kimura T, Kuwabara A, Yamazaki Y, Ohta H, Im DS, Sato K, Okajima F
Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.
Am J Physiol Heart Circ Physiol. 292:H2513-2522 (2007) [PubMed]

Kimura T, Tomura H, Mogi C, Kuwabara A, Damirin A, Ishizuka T, Sekiguchi A, Ishiwara M, Im DS, Sato K, Murakami M, Okajima F
Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high-density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.
J Biol Chem 281: 37457-37467 (2006) [PubMed]

Kimura T, Tomura H, Mogi C, Kuwabara A, Ishiwara M, Shibasawa, K, Sato K, Ohwada S, Im DS, Kurose H, Ishizuka T, Murakami M, Okajima F
Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells.
Cell Signal (2006) [PubMed]

Mogi C, Tomura H, Tobo M, Wang JQ, Damirin A, Kon J, Komachi M, Hashimoto K, Sato K, Okajima F
Sphingosylphosphorylcholine Antagonizes Proton-Sensing OGR1-Mediated Inositol Phosphate Production and cAMP Accumulation.
J Pharmacol Sci 99: 160-167 (2005) [PubMed]

Tomura H, Wang JQ, Komachi M, Damirin A, Mogi C, Tobo M, Kon J, Misawa N, Sato K, Okajima F
Prostaglandin I2 Production and cAMP Accumulation in Response to Acidic Extracellular pH Through OGR1 in Human Aortic Smooth Muscle Cells.
J Biol Chem 41: 34458-34464 (2005) [PubMed]

Tomura H, Mogi C, Sato K, Okajima F
Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors.
Cell Signal 17: 1466-1476 (2005) [PubMed]

Malchinkhuu E, Sato K, Horiuchi Y, Mogi C, Ohwada S, Ishiuchi S, Saito N, Kurose H, Tomura H, Okajima F
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.
Oncogene 24:6676-88 (2005) [PubMed]

Im YJ, Im DS, Lee YK, Lee EH, Sato K, Tomura H, Katada T, Ui M, Okajima F
Study on Action Mode of Sphingosine 1-Phosphate in Rat Hepatocytes.
J Pharmacol Sci 97:443-446 (2005) [PubMed]

Damirin A, Tomura H, Komachi M, Tobo M, Sato K, Mogi C, Nochi H, Tamoto K, Okajima F
Sphingosine-1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation Through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells.
Mol. Pharmacol 67:1177-1185 (2005) [PubMed]

Sato K, Malchinkhuu E, Muraki T, Ishikawa K, Hayashi K, Tosaka M, Mochiduki A, Inoue K, Tomura H, Mogi C, Nochi H, Tamoto K, Okajima F
Identification of Autotaxin as a Neurite Retraction-Inducing Factor of PC12 Cells in Cerebrospinal Fluid and Its Possible Sources.
J. Neurochem. 92: 904-914 (2005) [PubMed]

Tamama K, Tomura H, Sato K, Malchinkhuu E, Damirin A, Kimura T, Kuwabara A, Murakami M, Okajima F (2005)
High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component.
Atherosclerosis  178: 19-23 (2005) [PubMed]

Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K, Komachi M, Malchinkhuu E, Murata N, Kimura T, Kuwabara A, Wakamatsu K, Koizumi T, Uede T, Tsujimoto G, Kurose H, Sato T, Harada A, Misawa N, Tomura H, Okajima F
TDAG8 is a Proton-Sensing and Psychosine-Sensitive G-Protein-Coupled Receptor.
J Biol Chem 279: 45626-45633 (2004) [PubMed]

Im DS, Tomura H, Tobe M, Sato K, Okajima F
Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during g(0)-g(1) transition in rat hepatocytes.
J Pharmacol Sci 95:284-290 (2004) [PubMed]

Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T, Kuwabara A, Yanagita Y, Ikeya T, Tanahashi Y, Ogawa T, Ohwada S, Morishita Y, Ohta H, Im DS, Tamoto K, Tomura H, Okajima F
Lysophosphatidic acid in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
J Biol Chem 279:6595-6605 (2004) [PubMed]

Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Nishitoba T, Im D-S, Nochi H, Tamoto K, Tomura H, Okajima F
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Mol Pharmacol 64:994-1005 (2003) [PubMed]

Kimura T, Sato K, Malchinkhuu E, Tomura H, Tamama K, Kuwabara A, Murakami M, Okajima F
High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors.
Arterioscler Thromb Vasc Biol 23, 1283-1288 (2003) [PubMed]

Malchinkhuu E, Sato K, Muraki T, Ishikawa K, Kuwabara A, Okajima F
Assessment of the role of sphingosine 1-phosphateand its receptors in high-density lipoprotein-induced stimulation of astroglial cell function.
Biochem J 2003 370: 817-827 (2003) [PubMed]

Tamama K, kon J, Sato K, Tomura H, Kuwabara A, Kimura T, Kanda T, Ohta H, Ui M, Kobayashi I, Okajima F
Extracellular mechanism through Edg family of receptors may be responsible for sphimgosine 1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth muscle cells.
Biochem J 353: 139-146 (2001) [PubMed]

Kimura T, Sato K, Kuwabara A, Tomura H, Ishiwara M, Kobayashi I, Ui M, Okajima F
Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells.
J Biol Chem, 276: 31780-31785 ( 2001) [PubMed]

Yamazaki Y, Kon J, Sato K, Tomura H, Sato M, Yoneya T, Okazaki H, Okajima F, Ohta H
Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway.
Biochem Biophys Res Commun 268:583-589 (2000) [PubMed]

Kimura T, Watanabe T, Sato K, Kon J, Tomura H, Tamama Ki, Kuwabara A, Kanda T, Kobayashi I, Ohta H, Ui M, Okajima F
Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, edg-1 and edg-3.
Biochem J 348:71-6 (2000) [PubMed]

Murata N, Sato K, Kon J, Tomura H, Okajima F
Quantitative measurement of sphingosine 1-phosphate by radioreceptor-binding assay.
Anal Biochem 282:115-20 (2000) [PubMed]

Shimizu H, Okajima F, Kimura T, Ohtani K, Tsuchiya T, Takahashi H, Kuwabara A, Tomura H, Sato K, Mori M
Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets.
Endocrine J  47: 261-269 (2000) [PubMed]

Murata N, Sato K, Kon J, Tomura H, Kuwabara A, Ui M, Okajima F
Regulation by plasma components especislly lipoproteins of sphingosine 1-phosphate receptor-mediated actions.
Biochem J  352: 809-815 (2000) [PubMed]

Sato K, Ui M, Okajima F
Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells.
Mol Brain Res 85: 151-160 (2000) [PubMed]

Sato K, Tomura H, Igarashi Y, Ui M, Okajima F
Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells.
Mol Pharmacol 55:126-33 (1999) [PubMed]

Sato K, Kon J, Tomura H, Osada M, Murata N., Kuwabara A, Watanabe T, Ohta H, Ui M, Okajima F
Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor.
FEBS Lett 443:25-30 (1999) [PubMed]

Kon J, Sato K, Watanabe, Tomura H, Kuwabara A, Kimura T, Tamama K, Ishizuka T, Murata N, Kanda T, Kobayashi I, Ohta H, Ui M, Okajima F
Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells.
J Biol Chem 274:23940-7 (1999) [PubMed]

Sato K, Ishikawa K, Ui M, Okajima F
Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.
Mol Brain Res 74:182-189 (1999) [PubMed]

Okajima F, Sato K, Tomura H, Kuwabara A, Nochi H, Tamoto K, Kondo Y, Tokumitsu Y, Ui M
Stimulatory and inhibitory actions of lysophosphatidylcholine, depending on its fatty acid residue, on the phospholipase C/Ca2+ system in HL-60 leukaemia cells.
Biochem J 336:491-500 (1998) [PubMed]

Sato K, Murata N, Kon J, Tomura H, Nochi H, Tamoto K, Osada M, Ohta H, Tokumitsu Y, Ui M, Okajima F
Downregulation of mRNA expression of Edg-3, a putative sphingosine 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells.
Biochem Biophys Res Commun. 253(2):253-256 (1998) [PubMed]

Okajima F, Tomura H, Sho K, Kimura T, Sato K., Im DS, Kondo Y
Sphingosine1-phosphate stimulate hydrogen peroxide generation through activation of phospholipaseC-Ca2+ system in FRTL-5 thyroid cells: possible involvement of GTP-binding proteins in thelipid signaling.
Endocrinology 138: 220-229 (1997) [PubMed]

Tomura H, Itoh H, Sho K, Sato K, Nagao M, Ui M, Kondo Y, Okajima F
Betagamma subunits of pertussis toxin-sensitive G proteins mediate A1 adenosine receptor agonist-induced activation of phospholipase C in collaboration with thyrotropin. A novel stimulatory mechanism through the cross-talk of two types of receptors.
J Biol Chem 272(37):23130-23137 (1997) [PubMed]

Zannini M, Avantaggiato V, Biffali E, Arunone MI, Sato K, Pischetola M, Taylor BA, Phillips SJ, Simeone A, Di Lauro R
TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in contolling the onset of differentiation.
EMBO J 16(11):3185-97 (1997) [PubMed]

Sato K, Tomura H, Igarashi Y, Ui M, Okajima F
Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells.
Biochem Biophys Res Commun. 240(2):329-334 (1997) [PubMed]

Sato K, Di Lauro R
Hepatocyte Nuclear Factor 3β Participates in the TranscriptionalRegulation of the Thyroperoxidase Promoter.
Biochem Biophys Res Commun 220: 86-93 (1996) [PubMed]